Biological variation of thiopurine methyltransferase enzyme activity: when has a significant change taken place?
نویسندگان
چکیده
منابع مشابه
Genetic variation in the MTHFR gene influences thiopurine methyltransferase activity.
carbohydrate-deficient glycoprotein syndrome. Electrophoresis 1997;18: 1819–26. 12. Tagliaro F, Crivellente F, Manetto G, Puppi I, Deyl Z, Marigo M. Optimised determination of carbohydrate deficient transferrin isoforms (CDT) in serum by capillary zone electrophoresis. Electrophoresis 1998;19:3033–9. 13. Crivellente F, Fracasso G, Valentini R, Manetto G, Riviera AP, Tagliaro F. Improved method ...
متن کاملThiopurine methyltransferase genotype and thiopurine S-methyltransferase activity in Greek children with inflammatory bowel disease
BACKGROUND Azathioprine (AZA) and 6-mercaptopurine (6MP) are used in the treatment of pediatric inflammatory bowel disease (IBD). Genetic variations in thiopurine S-methyltranfarase (TPMT) gene have been correlated with enzyme activity and with the occurrence of adverse events to AZA and 6MP. The aim of the present study was to examine the sensitivity and specificity of TPMT genotyping for TPMT...
متن کاملThiopurine S-methyltransferase and Pemphigus Vulgaris: A Phenotype-Genotype Study
Background & Objective: Thiopurine drugs are considered as a treatment modality in various autoimmune disorders including pemphigus vulgaris (PV). These drugs are metabolized by an enzyme “Thiopurine S-methyl transferase” (TPMT). Various variants of this enzyme may have decreased activity lead...
متن کاملPharmacogenetics of thiopurine S-methyltransferase and thiopurine therapy.
Most medications exhibit wide interpatient variability in their efficacy and toxicity. For many medications, these interindividual differences result in part from polymorphisms in genes encoding drug-metabolizing enzymes, drug transporters, and/or drug targets (eg, receptors, enzymes). Pharmacogenomics is a burgeoning field aimed at elucidating the genetic basis of differences in drug efficacy ...
متن کاملAssessment of thiopurine methyltransferase activity in patients prescribed azathioprine or other thiopurine-based drugs.
OBJECTIVES To examine whether pretreatment determination of thiopurine methyltransferase (TPMT) enzymatic activity (phenotyping) or TPMT genotype, to guide thiopurine therapy in chronic autoimmune disease patients, reduces treatment harms. Other objectives included assessing: preanalytic, analytic, and postanalytic requirements for TPMT testing; diagnostic accuracy of TPMT genotyping versus phe...
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ژورنال
عنوان ژورنال: Annals of Clinical Biochemistry: International Journal of Laboratory Medicine
سال: 2013
ISSN: 0004-5632,1758-1001
DOI: 10.1177/0004563212473441